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Home / News / Introduction to the pharmacological action of mangiferin

Introduction to the pharmacological action of mangiferin

Views:0     Author:Site Editor     Publish Time: 2021-11-17      Origin:Site

Brief introduction to the pharmacological effects of mangiferin

1. Antioxidant effect

Due to the special structure of mangiferin, there are multiple phenolic hydroxyl groups in the molecule, and the phenolic hydroxyl group happens to be an important group for scavenging free radicals and active oxygen. Its mechanism of action on free radicals can be attributed to two aspects: on the one hand, it directly acts on scavenging free radicals, on the other hand, it acts on iron and copper ions to reduce its further reaction with free radicals.

2. Anti-tumor effect

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3. Neuroprotective effect

Mangiferin with a polyphenol structure can reduce Ca2+ influx and oxidative stress, thereby reducing cell death caused by glutamate in neurons to protect neurons.

4. Antiviral effect

It has an in vitro anti-herpes simplex virus type I (HSV-I) effect, with a plaque reduction rate of 56.8%. Its antiviral effect is attributed to its ability to inhibit viral replication in cells.

5. The antipyretic effect

It applies to the experimental animal model of fever caused by endotoxin and is positively correlated with the dose. The antipyretic effect has a good protective effect on heat damage.

6. The analgesic effect

The significant effect applies to the pain induced by acetic acid and the hot plate test. By comparing with naloxone hydrochloride, it is found that mangiferin-induced analgesia is not dependent on opioid receptors, and its analgesic effect on Chemicalbook is significant. The effect on peripheral nerves is slight.

7. Anti-parasitic effect

Mangiferin has a significant inhibitory effect on Cryptosporidium parvum in young mice. The effect of mangiferin on mice infected with nematodes and Trichinella spiralis.

8. Anti-diabetic effect

After oral administration of mangiferin and its glucoside, the blood glucose level of normal mice has no change, but it can reduce the blood glucose concentration of spontaneous diabetes animal model KK-Ay mice, and the serum insulin level also has a tendency to decrease. Fructin and its glucoside may show anti-diabetic activity through insulin sensitization.

9. Hepatoprotective and choleretic effect on the liver

Mangiferin has the effect of stabilizing the lysosomal membrane, and has a direct inhibitory effect on the activity of lysosomal acid phosphatase. Mangiferin also has obvious choleretic effects.

10. Effects on the central nervous system

Mangiferin has obvious central nervous system excitatory effects. Mangiferin has the effect of clearing lipid peroxide in brain tissue, reducing the damage of lipid peroxide to neurons, thereby protecting the normal function of neurons.

11. Effects on the respiratory system

The effect on the respiratory system has an adrenal glucocorticoid-like anti-inflammatory effect, which can reduce capillary permeability, and its anti-inflammatory response rate reaches 38%. Due to the anti-inflammatory effect of mangiferin, it has a certain effect on bronchial asthma, manifested as:

a. It can significantly prolong the time of inducing asthma compared with the asthma group;

b. It can reduce the degree of asthma and the incidence of convulsions is significantly lower than that of the asthma group;

c. It can significantly reduce emphysema, and the infiltration of inflammatory cells in the lungs is significantly less than that of the asthma group. The weight ratio was significantly lower than that of the asthma group and close to that of the dexamethasone group. At the same time, mangiferin can reduce the level of serum NO and endothelin-1 (ET-1) in the alveolar lavage fluid, and play a certain preventive effect on asthma attacks. The combination of mangiferin and dexamethasone can improve the efficacy.


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