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The plant extract Magnolia officinalis Rehd is from Magnoliaceae etWils. Magnolia officinalis Rehd etWils. var.bilobaRehd. etWils. It is an active substance extracted from dry skin, branch skin and root skin, which has the effects of antibacterial, anti-inflammatory, anti-tumor, anti endomycin, muscle relaxation and relieving acute inflammatory pain. In terms of antibacterial effect, magnolol has significant antibacterial activity against Gram-positive bacteria, acid resistant bacteria and filamentous fungi, has more significant antibacterial effect on Streptococcus mutans, and has the strongest inhibitory effect on Staphylococcus. Clinically, it is mainly used to eliminate chest and abdomen fullness, calm the central nervous system, athletes' muscle relaxation, antifungal, anti ulcer and other drugs. [habitat and distribution] it often grows in mixed forests at the foot of hillsides and roadside streams at an altitude of 800 ~ 1700 meters. It is a light loving mesophytic tree species; Like cool, chemicalbook humid climate. The soil layer should be deep, fertile, loose, rich in humus and slightly acidic or neutral soil with good drainage. It is mainly produced in Enshi, Jianshi, Badong, Yichang, Lichuan, Chongqing Chengkou, Kaixian, Wuxi, Wushan, Shizhu, Wulong and Fengjie. It is also distributed in Yunyang, Wanzhou, Zhongxian, Fengdu, Fuling, Jiangjin, Qianjiang, Pengshui, Xiushan, Nanchuan and other places in Chongqing. [plant form] deciduous tree, 7 ~ 15m high. The bark is purplish brown, and the winter buds are covered by stipules, which fall off after opening. Single leaves alternate, gathered at the top of branchlets, leaves elliptic obovate, 20 ~ 45cm long and 10 ~ 25cm wide, apex obtuse or mucronate, base cuneate or round, entire or microwave shaped, back covered with gray white short villi when young and white powder when old. Flowers and leaves open at the same time, single branch top, white, fragrant, about 15cm in diameter, stout pedicel, covered with brown hair; Perianth segments 9 ~ 12; Stamens numerous; Pistil carpels numerous, arranged on elongated receptacle. Aggregate fruit oval, woody, with 1 seed per chamber. The flowering period is from April to May and the fruiting period is from September to October.
Brown to white fine powder. The monomer is colorless acicular crystal. The melting point is 102 ℃. It is easy to dissolve in common organic solvents such as benzene, chloroform and acetone, difficult to dissolve in water and easy to dissolve in dilute caustic alkali solution. Applied Magnolia officinalis total phenol is a phenolic mixture extracted from traditional Chinese medicine Magnolia officinalis. It has many biological functions, such as antiviral, antibacterial, anti-inflammatory and anti diarrhea. The antioxidant effect of Magnolia officinalis total phenol is an important basis for its biological function. Pharmacological action magnolol is a diphenylene propylene compound, white to yellowish brown powder, fragrant, pungent and slightly bitter. It is the main active ingredient of Magnolia officinalis. It is a small molecular natural product extracted from the dry skin, root skin and branch skin of Magnolia officinalis or concave leaf Magnolia officinalis. It has anti-inflammatory, antibacterial, cardiovascular and cerebrovascular system protection, anti anxiety and depression, muscle relaxation, anti-oxidation Improve gastrointestinal dysfunction and antitumor effects. The water extract of Magnolia officinalis has a significant curare like effect. Its alcohol extract can reduce the grip strength and strongly inhibit the spasm induced by strychnine, picrotoxin and other drugs. It can relieve intestinal spasm caused by barium chloride and pilocarpine, and inhibit the contraction of isolated guinea pig bronchial smooth muscle caused by histamine. Magnolia officinalis, a water-soluble alkaloid isolated from Magnolia officinalis, has a relaxing effect on striated muscle and can block the transmission of impulse in motor endplate, so it has a nerve muscle blocking effect. Honokiol has antibacterial effect on Gram-positive bacteria such as Staphylococcus, pneumococcus and hemolytic streptococcus, and Gram-negative bacteria such as dysentery bacillus, typhoid bacillus, Escherichia coli and Bacillus subtilis. The ether extract of Magnolia officinalis can reduce the spontaneous activity of mice and resist the excitement caused by methamphetamine or apomorphine. Magnolol and isomagnolol also have significant central inhibitory effect of chemicalbook. Magnolol can completely inhibit the spinal cord reflex in mice, and ether extract 0.25 ~ 1g / kg can show the central inhibitory effect of disappearing any reflex. Houpu raw products and ginger roasted products have anti gastric ulcer effects on pyloric ligation type and stress type II acute experimental gastric ulcer models in rats, especially ginger products. Magnolol 100mg / kg intraperitoneal or subcutaneous injection can inhibit water immersion restraint stress ulcer, Mercaptoethylamine ulcer and pyloric ligation ulcer, and antagonize the effect of central gastric acid secretion stimulator. Chemical properties: soluble in benzene, ether, chloroform, acetone and common organic solvents, difficult to dissolve in water. It comes from Magnoliaceae deciduous tree magnoliaofficinalis Rehd etWils. Use: used for content determination / identification / pharmacological experiment, etc. Pharmacological efficacy: magnolol has obvious and lasting central muscle relaxation, central nerve inhibition, anti-inflammatory, antibacterial, antiviral, anti ulcer, antioxidant, anti-tumor, inhibiting morphine withdrawal reaction, inhibiting platelet aggregation and other pharmacological effects. Magnolol is used to treat acute enteritis Bacillary or amoebic dysentery Chronic gastritis, etc. Among them, in terms of antibacterial effect, magnolol has significant antibacterial activity against Gram-positive bacteria, acid resistant bacteria and filamentous fungi, has more significant antibacterial effect on Streptococcus mutans, and has the strongest inhibitory effect on Staphylococcus. Clinically, it is mainly used to eliminate chest and abdomen fullness, calm the central nervous system, athletes' muscle relaxation, antifungal, anti ulcer and other drugs. Uses bioactive substances with antifungal, antibacterial and antioxidant properties, and by interfering with NF- κ B signal transduction, which has anti-inflammatory activity.