Email Us :
Cal Us : +86 18691847636
Home / News / Rhein has seven pharmacological effects

Rhein has seven pharmacological effects

Views:0     Author:Site Editor     Publish Time: 2021-10-04      Origin:Site

1. Anti-tumor activity

Rhein has a certain inhibitory effect on mouse melanoma, liver cancer, Ehrlich ascites cancer, breast cancer, and P388 leukemia cells. Intraperitoneal injection of rhein 50μg/kg for 21 days, the inhibition rate of melanoma in mice was 76%. The IC50 value of the inhibitory effect on Ehrlich's ascites cancer is 40μg/kg. One of the mechanisms of its inhibitory effect on liver cancer in vivo and liver cancer in mice with ascites is to affect its three-dimensional and microfilament structure.

2. Antibacterial activity

Rhein (Rhein) at a depth of 1.5-25mg/ml has inhibitory effects on Staphylococcus, Paratyphoid, Streptococcus, Bacillus subtilis, Diphtheria, Shigella, etc. One of its mechanism of action is to inhibit electron transfer in the mitochondrial respiratory chain. In addition, rhein has a strong inhibitory effect on the protein and nucleic acid synthesis of Staphylococcus aureus, and also has an inhibitory effect on the DNA biosynthesis of cell-free systems.rhapontic rhubarb benefits-jiaherbio

3. Anti-inflammatory effect

The 1,8-diacetyl compound of rhein is currently used to treat osteoarthritis. The acetyl group of 1,8-Diacelyrhein (1,8-Diacelyrhein) can be completely hydrolyzed in the intestine, and the effective substance form should be rhein.

4. Immunosuppressive effect

Rhein can inhibit the production of biological antibodies, inhibit the ability of carbon particle clearance, reduce the weight of immune organs, and reduce the number of white blood cells.

5. Diuretic effect

Rhein can increase the concentration of sodium and potassium ions in urine, promote ureteral peristalsis, thereby increasing urine output.

6. Purging effect 

In fact, rhein (Rhein) itself has no diarrhea effect. Its intestinal bacteria conversion product rhein anthrone has diarrhea activity, which can reduce the absorption of sodium and chloride ions in the colon and increase the secretion of potassium ions. Prostaglandins play an important role in the laxative activity of rhein anthrone. 

7. Treatment of diabetic nephropathy

Studies have shown that rhein has the unique curative effect and new pharmacodynamic characteristics of improving abnormal glucose metabolism, reversing insulin resistance, and effectively preventing diabetic nephropathy. It is not available in the currently known drugs for the treatment of diabetic nephropathy, and has good safety.

Quick Links

Contact us
Copyright © 2021Xi'an Xian Jiahe Biotech Co., Ltd. All Rights Reserved.丨Sitemap