Views: 0 Author: Site Editor Publish Time: 2022-06-15 Origin: Site
Magnolol is a biphenol compound and the main active ingredient of the traditional Chinese medicine Magnolia officinalis. In 1930, Japanese Sugii first isolated magnolol from the bark of Magnolia officinalis in my country. Magnolol is brown to white fine powder, fragrant, pungent and slightly bitter. The monomer is a colorless needle crystal (water) with a melting point of 102°C. Soluble in benzene, ether, chloroform, acetone and common organic solvents, insoluble in water, easily soluble in dilute caustic alkali solution to obtain sodium salt. Magnolol has antibacterial, anti-inflammatory, antioxidant, anti-tumor effects, and can also relieve muscle tension and relax muscles.
1. Antibacterial effect
Magnolol has obvious antibacterial effect, and the minimum inhibitory concentration (MIC) of Trichophyton mentagrophytes, Microsporum gypsum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans and Candida albicans are all 25, --,100pg/mLtl0]; the minimum inhibitory concentration (MIC) for Bacillus subtilis and Mycobacterium smegmatis were 51. tg/mlt¨]. Honokiol can kill oral bacteria and eliminate bad breath, making it one of the main ingredients in mints and chewing gum.
2. Anti-inflammatory effect
Honokiol can dose-dependently inhibit lymphocyte budding, mouse ear swelling, reduce the permeability of capillary walls around the inflammatory site, inhibit leukocyte migration and fibrous tissue proliferation, and can also change the pattern of cytokines in inflammatory-related diseases. Reduce inflammatory factors and increase the production of anti-inflammatory factors. Shih HC and other studies have found that the concentration of tumor necrosis factor-a (TNF. only) in plasma and tissue will increase during hemorrhagic shock, and the anti-inflammatory representative factor interleukin. 10(Ⅱ, lO) has no change in the organ tissue. The application of honokiol can reduce the concentration of the former and correspondingly increase the content of the latter in the lungs. The anti-inflammatory effect of honokiol may be related to the inhibition of the metabolic pathway of AA, and it may also be related to the inhibition of intracellular lysosome release. Researchers from the Fujian Provincial Corps Hospital of the Armed Police prepared rat neutrophil suspensions, and measured the generation of superoxide anion, p. Glucuronidase release and lysozyme release. The results showed that honokiol can reduce the production of superoxide anion in neutrophils at 1～1009M/L, and can obviously inhibit the activated neutrophils when it is greater than 109M/L p. Release of glucuronidase and lysozyme. In addition, honokiol can also attenuate gastroenteritis caused by sepsis.
3. Muscle relaxant and antioxidant
Honokiol has pronounced, long-lasting muscle-relaxing effects. Wang Jp et al. used mice with sepsis induced by intraperitoneal injection of lipopolysaccharide as experimental materials. The study showed that honokiol can effectively promote intestinal transit and play a role in muscle relaxation. Compared with mice without honokiol In contrast, tumor necrosis factor (TNF. only), chemotactic protein. 1. The mRNA synthase is also significantly reduced, and it also has antioxidant activity. Zhao Xiang B et al. found that honokiol could inhibit the muscle contraction induced by 40 mM potassium chloride, 1 ttM carbonylcholine and 109M serotonin in a dose-dependent manner, and the application of honokiol above 109M could inhibit the Influx and release of calcium ions.
4. Anti-tumor effect
Honokiol can induce apoptosis of leukemia cells by inhibiting Staphylococcus aureus and fungi. Honokiol can inhibit the activation of Epstein-Barr virus early antigens induced by the tumor promoter TPA, and also has a strong inhibitory effect on mouse skin tumors caused by the phase II carcinogenicity test in vivo. While inhibiting tumor cell apoptosis, honokiol is nontoxic to normal neutrophils and surrounding blood mononuclear cells. Honokiol can inhibit the activities of uroglycate diphosphate glucuronyltransferase and superoxide dismutase required for the oxidation reaction, and inhibit the mutation of cells. Saito et al. studied mice induced by benzopyrene (a powerful carcinogen) and found that honokiol could significantly inhibit cell mutation in these mice.
5. Effects on the nervous system
Honokiol has obvious anti-anxiety effects. Honokiol can stimulate the opening of chloride ion channels, so that the cell membrane is in a hyperpolarized state, and the hyperpolarized state will reduce the excitability of neuronal cells, thereby achieving anxiolytic effects. Honokiol can significantly inhibit the morphine withdrawal response, which is closely related to p. related to endorphins and in a dose-effect relationship.
6. Other functions
Honokiol also has cardioprotective effects, inhibits the occurrence of ventricular fibrillation and death, and inhibits arrhythmia. Honokiol has inhibitory effects on Shay's pyloric ligation, water-immersed stress gastric ulcer, and histamine-induced duodenal spasm.
Honokiol can inhibit skin aging by inhibiting nuclear transcription factor kB, and the addition of this drug ingredient in sunscreen has achieved good market returns. Another study has shown that honokiol can also become a candidate drug for the treatment of alcoholic fatty liver through anti-oxidation and other effects. Honokiol can significantly inhibit the aggregation of rabbit platelet-rich plasma induced by collagen and arachidonic acid, and inhibit the release of ATP.