Views:0 Author:Site Editor Publish Time: 2022-01-12 Origin:Site
Chondroitin sulfate (CS) is a kind of glycosaminoglycans covalently linked to proteins to form proteoglycans. Chondroitin sulfate is widely distributed in the extracellular matrix and cell surface of animal tissues. The sugar chain is polymerized by alternating glucuronic acid and N-acetylgalactosamine, and connected to the serine residue of core protein through a sugar like link region.
Although the main chain structure of polysaccharide is not complex, it shows a high degree of heterogeneity in terms of the degree of sulfation, sulfate group and the distribution of the two differences to the re chain of isouronic acid. The fine structure of chondroitin sulfate determines the functional specificity and interaction with a variety of protein molecules.
The main application way in medicine is as a drug for the treatment of joint diseases, which is used in combination with glucosamine. It has the effect of relieving pain and promoting cartilage regeneration, and can fundamentally improve joint problems.
Randomized placebo-controlled clinical trials have proved that chondroitin sulfate can reduce pain in patients with osteoarthritis, improve joint function, reduce joint swelling and effusion, and prevent space stenosis in knee and hand joints. It provides a cushion to ease the impact and friction during action, absorb water into proteoglycan molecules, thicken cartilage and increase the amount of synovial fluid in joints. One of the important functions of chondroitin is to serve as a delivery pipeline to deliver important oxygen supply and nutrients to the joint, help remove waste in the joint, and eliminate carbon dioxide and waste at the same time. Because articular cartilage has no blood supply, all oxygenation, nourishment and lubrication come from synovial fluid.